- Title
- Species-specific regulation of t-PA and PAI-1 gene expression in human and rat astrocytes
- Creator
- Tjärnlund-Wolf, Anna; Hultman, Karin; Blomstrand, Fredrik; Nilsson, Michael; Medcalf, Robert L.; Jern, Christina
- Relation
- Gene Regulation and Systems Biology Vol. 2014, Issue 8, p. 113-118
- Publisher Link
- http://dx.doi.org/10.4137/GRSB.S13387
- Publisher
- Libertas Academica
- Resource Type
- journal article
- Date
- 2014
- Description
- In recent years, the role and physiological regulation of the serine protease tissue-type plasminogen activator (t-PA and its inhibitors, including plasminogen activator inhibitor type-1 (PAI-1, in the brain have received much attention. However, as studies focusing these issues are difficult to perform in humans, a great majority of the studies conducted to date have utilized rodent in vivo and/or in vitro models. In view of the species-specific structural differences present in both the t-PA and the PAI-1 promoters, we have compared the response of these genes in astrocytes of rat and human origin. We reveal marked quantitative and qualitative species-specific differences in gene induction following treatment with various physiological and pathological stimuli. Thus, our findings are of importance for the interpretation of previous and future results related to t-PA and PAI-1 expression.
- Subject
- astrocytes; tissue-type plasminogen activator; plasminogen activator inhibitor type-1; gene expression; species-specific
- Identifier
- http://hdl.handle.net/1959.13/1302623
- Identifier
- uon:20514
- Identifier
- ISSN:1177-6250
- Language
- eng
- Full Text
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